Pueraria candollei var. mirifica Airy Shaw root: A Unique Thai Botanical Medicine with Potential as a U.S. Dietary Supplement for Oral and Topical Use
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منابع مشابه
Production of isoflavonoids in callus cultures of Pueraria candollei var. mirifica.
Pueraria candollei Wall. ex Benth. var. mirifica (Airy Shaw & Suvat.) Niyomdham was investigated for callus induction using Murashige and Skoog (MS) medium containing different plant growth regulators. After 8 weeks of culture, 66-100% of leaf or stem explants formed calli. Calli from stem explants cultured on MS medium supplemented with 0.5 mg/l thidiazuron (TDZ) gave the maximum of shoot indu...
متن کاملEffects of Pueraria mirifica and miroestrol on the antioxidation-related enzymes in ovariectomized mice.
OBJECTIVES The influences of Pueraria candollei var. mirifica (PM), a Thai medicinal plant with long tradition of medicinal consumption among menopausal women for rejuvenation and estrogen hormone replacement, on oxidative status in ovariectomized (OVX) mice were determined. METHODS The crude extract of PM and its active phytoestrogen, miroestrol (MR), were given to OVX mice. The effect of th...
متن کاملInhibitory Potentials of Five Phytoestrogens from Pueraria candollei var. mirifica on CYP1A1 and CYP1A2 Proteins in Mouse Liver Microsomes and in silico
Pueraria candollei var. mirifica (PM) is a Thai traditional medicinal plant for rejuvenation and estrogen replacement therapy in menopausal women. CYP1A1 and CYP1A2 proteins are the members of hepatic cytochrome P450 (CYP) enzymes to activate a procarcinogen, in which ethoxyresorufin O-demethylase (EROD) and methoxyresorufin O-demethylase (MROD) activities are the specific markers for CYP1A1 an...
متن کاملEstrogen-like activities and cytotoxicity effects of Thai herbal medicines as natural ingredients in anti-ageing
The objective of the study was to search for the appropriate herbal extracts by comparative analysis of their estrogenic and cytotoxic activities. Some potentially estrogenic activity of herbal extracts in the management of female disorder symptoms was investigated by E-screen assay. The extracts having a promising activity were further evaluated in vitro for their cytotoxic activity. Of 13 her...
متن کاملDown regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol.
Miroestrol and deoxymiroestrol are phytoestrogens isolated from tuberous root of Pueraria candollei var. mirifica. Modulatory effects of miroestrol and deoxymiroestrol on enzymes involved in sex-hormone synthesis pathway in male C57BL/6 mice were investigated using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Miroestrol and deoxymiroestrol suppressed the expressio...
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